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Doccol线拴是国际脑缺血研究中应用最多的线拴,也是Nature,Stroke,J Neurosci 等顶级杂志报道最多的线拴。根据谷歌学术的搜索结果,截止至2018年9月,已经有数千篇研究脑缺血的文献引用了Doccol线栓;仅2018年1月至9月就有158篇,目录如下。


New articles referring Doccol from January to September in 2018

(according to google scholar)

Modeling Transient Focal Ischemic Strokein Rodents by Intraluminal Filament Method of Middle Cerebral Artery Occlusion

MS Lopez, R Vemuganti - Traumatic and Ischemic Injury, 2018 - Springer
… Middle cerebral artery occlusion (MCAO) has been a valuable model of focal ischemic stroke since 1981, when Tamura et al. [1] demonstrated permanent occlusion in the distal MCA via craniectomy … (18a) MCAO filaments for mice (Doccol, #6023) …
Related articles All 4 versions

MRI in the Study of Animal Models of stroke

P Ramos-Cabrer, D Padro - Preclinical MRI, 2018 - Springer
… 3.1 stroke Model: Occlusion of the Medial Cerebral Artery (MCAo) … A nylon filament with a rounded silicone tip may do the job, but we strongly recommend commercial suture L34 PK10 from Doccol—see materials section—to increase success rate and reproducibility) is …
Related articles All 4 versions

Reducing myeloperoxidase activity decreases inflammation and increases cellular protection in ischemic stroke

HJ Kim, Y Wei, GR Wojtkiewicz… - Journal of Cerebral …, 2018 - journals.sagepub.com
Myeloperoxidase (MPO) is a pro-inflammatory enzyme abundantly secreted by activated myeloid cells after stroke. We show that when MPO activity is either blocked... 
A small nick was made in the ECA stump and a 7-0 fine surgical nylon monofilament (diameter
0.19-0.20 mm) coated with silicon (Cat # 7019PK5Re, Doccol Co., Sharon, MA, USA) was
inserted into the right ICA lumen through the ECA stump and advanced up to the MCA origin at
the Circle of Willis.
Related articles All 3 versions

[HTML] Immunomodulatory treatment with systemic GM-CSF augments pulmonary immune responses and improves neurological outcome after experimental stroke

C Dames, K Winek, Y Beckers, O Engel… - Journal of …, 2018 - Elsevier
… and water. 2.2. Experimental stroke (middle cerebral artery occlusion, MCAo). The middle cerebral … Berlin (Dirnagl, 2010). In brief, after ventral cervical incision a silicon-coated filament (7019PK5Re, Doccol Corp. Redlands, California …
Cited by 1 Related articles All 6 versions

[HTML] Vitamin D3 Supplementation Reduces Subsequent Brain Injury and Inflammation Associated with Ischemic stroke

MA Evans, HA Kim, YH Ling, S Uong, A Vinh… - Neuromolecular …, 2018 - Springer
… Animals were injected ip for 5 consecutive days prior to experimental stroke and again on the day of the procedure, as previously described … xylazine: 10 mg/kg ip) by occlusion of the middle cerebral artery (MCA) using a 6.0 silicone-coated monofilament (Doccol Corporation) …
Cited by 2 Related articles All 5 versions

Ischemic Strokedetection by analyzing heart rate variability in rat middle cerebral artery occlusion model

T Kodama, K Kamata, K Fujiwara… - … on Neural Systems …, 2018 - ieeexplore.ieee.org
… to the common carotid artery (CCA) and a nylon monofilament coated with silicon resin (5-0 large MCAO suture B3 L23 PK10, Doccol Corporation) is inserted through ECA to occlude the right MCA. It is important to investigate the area and volume of ischemic stroke in the brain …
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[HTML] Myeloid-specific TAK1 deletion results in reduced brain monocyte infiltration and improved outcomes after stroke

A Chauhan, J Hudobenko… - Journal of …, 2018 - jneuroinflammation.biomedcentral …
… A midline ventral neck incision was made, and unilateral MCAO was performed by inserting a 6.0 Doccol monofilament (Doccol Corp, Redlands, CA, USA) into the right internal carotid … Following reperfusion, mice were sacrificed at day 3 after stroke …
Related articles All 7 versions

T Cells Prevent Hemorrhagic Transformation in Ischemic Strokeby P-Selectin Binding

A Salas-Perdomo, F Miró-Mur, X Urra… - … , and vascular biology, 2018 - Am Heart Assoc
… 38, No. 8T Cells Prevent Hemorrhagic Transformation in Ischemic stroke by P-Selectin Binding. No Accessarticle Download PDF … Supplementary Materials. No Accessarticle Download PDF. T Cells Prevent Hemorrhagic Transformation in Ischemic stroke by P-Selectin Binding …
Occlusion of the right middle cerebral artery (MCAo) was performed under isoflurane anesthesia using a monofilament (no. 701912PK5Re, Doccol Corporation, Sharon, MA), ...
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AKAP1 protects from cerebral ischemic Strokeby inhibiting Drp1-dependent mitochondrial fission

KH Flippo, A Gnanasekaran, GA Perkins… - Journal of …, 2018 - Soc Neuroscience
… We found that AKAP1 loss worsens 101 outcomes of transient MCAO, a model of focal ischemic stroke. Indicative of Drp1 hyperactivation, 102 … siliconized filament (Doccol Corp.) followed by 23 hours of reperfusion. Body temperature was 126 …
All 5 versions

SIRT2 Inhibition Confers Neuroprotection by Downregulation of FOXO3a and MAPK Signaling Pathways in Ischemic stroke

DT She, LJ Wong, SH Baik, TV Arumugam - Molecular neurobiology, 2018 - Springer
… and non-histones pro- teins, and modulations of sirtuins have been showed to signif- icantly dictate the outcome of ischemic stroke [11] … was cut and a 6-0 monofilament with the tip blunted and coated with silicone rubber (0.21–0.23 mm in diameter, Doccol Corporation, Sharon …
Cited by 2 Related articles All 3 versions

Impaired Neurofilament Integrity and Neuronal Morphology in Different Models of Focal Cerebral Ischemia and Human StrokeTissue

B Mages, S Aleithe, S Altmann, A Blietz… - Frontiers in cellular …, 2018 - frontiersin.org
… Further details on the analyzed brain tissue and stroke characterization are given in Kattah et al … 33 mg/kg body weight, Hypnomidate, Janssen-Cilag, Neuss, Germany) followed by insertion of a standardized silicon-coated 6-0 monofilament (Doccol Corporation, Redlands, CA …
All 2 versions

Stepwise impairment of neural stem cell proliferation and neurogenesis concomitant with disruption of blood-brain barrier in recurrent ischemic stroke

R Lin, M Lang, N Heinsinger, G Stricsek, J Zhang… - Neurobiology of …, 2018 - Elsevier
… For the first stroke (MCAO), the rats were placed supine after anesthesia and MCAO was performed using a slight modification of our … Briefly, the right common carotid (CCA) was temporally ligated and a silicone rubber-coated nylon filament (Doccol) was inserted into the ECA …
Cited by 2 Related articles All 3 versions

[HTML] Protective Effects of L-902,688, a Prostanoid EP4 Receptor Agonist, against Acute Blood-Brain Barrier Damage in Experimental Ischemic stroke

KM DeMars, AO McCrea, DM Siwarski… - Frontiers in …, 2018 - frontiersin.org
… To mimic ischemic stroke, rats were subjected to 90 min of transient middle cerebral artery occlusion (MCAO) using the intraluminal filament … the CCA a few millimeters above the ligation to allow for a 4-0 silicone-coated filament (Cat # 403523PK10; Doccol Corporation, Sharon …
Related articles All 5 versions

[HTML] CNS-border associated macrophages respond to acute ischemic Strokeattracting granulocytes and promoting vascular leakage

J Pedragosa, A Salas-Perdomo… - Acta …, 2018 - actaneurocomms.biomedcentral …
… damage and triggers sterile inflammation and innate immune responses [5, 26] that are considered as putative targets for therapeutic intervention [4]. While the responses of microglia to ischemic stroke have been … The MCA was occluded with a filament (Doccol #403912PK10Re …
All 7 versions

Apixaban decreases brain thrombin activity in a male mouse model of acute ischemic stroke

D Bushi, J Chapman, A Wohl, ES Stein… - Journal of …, 2018 - Wiley Online Library
… 2.2 Effect of apixaban on brain thrombin activity and infarct volume following focal ischemic stroke … Permanent MCA occlusion (pMCAo) was performed as previously reported by our lab (Bushi et al., 2013, 2015, 2016) using silicone‐coated filament (Doccol Corp, Redlands, CA …
Related articles All 3 versions

Acute mitogen‐activated protein kinase 1/2 inhibition improves functional recovery and vascular changes after ischaemic Strokein rat‐monitored by 9.4 T magnetic …

M Mostajeran, F Wetterling, F W. Blixt… - Acta …, 2018 - Wiley Online Library
… potential in the future because it clearly shows a beneficial effect after stroke even when administrated 6 hours after stroke onset … A silicon rubber‐coated monofilament (Doccol Corporation, MA, USA) was inserted into the right internal carotid artery and further advanced until the …
Cited by 1 Related articles All 6 versions

Selective role of Na+/H+ exchanger in Cx3cr1+ microglial activation, white matter demyelination, and post‐Strokefunction recovery

S Song, S Wang, VM Pigott, T Jiang, LM Foley… - Glia, 2018 - Wiley Online Library
Silicone‐coated suture was from Doccol (Redlands, CA, USA) … Krieger, Tetzlaff, & Rossi, 2007; Fogg et al., 2006; Valny, Honsa, Kirdajova, Kamenik, & Anderova, 2016) and for replenishing of Cx3cr1 + monocytes (Parkhurst et al., 2013) prior to induction of ischemic stroke …
All 4 versions

Beta adrenoceptor blockade ameliorates impaired glucose tolerance and alterations of the cerebral ceramide metabolism in an experimental model of ischemic stroke

S Luger, A Schwebler, R Vutukuri… - Therapeutic …, 2018 - journals.sagepub.com
Background: Sphingolipids are versatile signaling molecules derived from membrane lipids of eukaryotic cells. Ceramides regulate cellular processes such as prol...
Focal cerebral ischemia was induced after a midline cervical incision and exposure of the right carotid bifurcation by introducing a standardized silicone-coated monofilament with a tip diameter of 0.23 mm (Doccol, Redlands, CA, USA) and advancing it along the internal carotid artery until the tip occluded the proximal stem of the middle cerebral artery.
Related articles All 5 versions

[HTML] Inhibition of the NLRP3-inflammasome as a potential approach for neuroprotection after stroke

S Ismael, L Zhao, S Nasoohi, T Ishrat - Scientific reports, 2018 - nature.com
Article | Open. Inhibition of the NLRP3-inflammasome as a potential approach for neuroprotection after stroke … animals. Full size image. MCC950 treatment prevents stroke-induced NLRP3 inflammasome activation. The principal …
Middle cerebral artery occlusion (MCAO) was achieved using a 6–0 silicon-coated nylon suture (Doccol, Sharon, MA), advanced into the internal carotid artery to block the origin of the middle cerebral artery.
Cited by 3 Related articles All 8 versions

Vascular endothelial growth factor isoform-B stimulates neurovascular repair after ischemic Strokeby promoting the function of pericytes via vascular endothelial …

NJ LeBlanc, R Guruswamy, A ElAli - Molecular neurobiology, 2018 - Springer
… Adult C57BL6/j male mice (3 months old) were subjected to focal ischemic stroke via the transient occlusion of the MCA using an … A microvascular clip was placed on the internal carotid artery, and a 7–0 silicon-coated nylon monofilament (Doccol Corporation, MA, USA) was ited by 9 Related articles All 3 versions

The combination of mannitol and temozolomide increases the effectiveness of stem cell treatment in a chronic Strokemodel

C Choi, HM Kim, J Shon, J Park, HT Kim… - …, 2018 - celltherapyjournal.org
… The combination of mannitol and temozolomide increases the effectiveness of stem cell treatment in a chronic stroke model … Email the author Ok Joon Kim. The combination of mannitol and temozolomide increases the effectiveness of stem cell treatment in a chronic stroke model …
The external branch of the carotid artery (ECA) was punctured and filaments (Doccol Corp.) were inserted to block the middle cerebral artery. After 60 min, the ...
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Plasma Unesterified Fatty‐Acid Profile Is Dramatically and Acutely Changed under Ischemic Strokein the Mouse Model

SA Golovko, MY Golovko - Lipids, 2018 - Wiley Online Library
… These results are the first to identify plasma FFA pro- files as a potential biomarker for early ischemic stroke within the … Briefly, mice were anesthetized with 1.75–2.25% isoflurane, and a standard- ized microfilament (702345PK5Re, Doccol Corporation, Sharon, MA, USA) was …
All 3 versions

KLF4 protects brain microvascular endothelial cells from ischemic strokeinduced apoptosis by transcriptionally activating MALAT1

H Yang, X Xi, B Zhao, Z Su, Z Wang - Biochemical and biophysical …, 2018 - Elsevier
… long noncoding RNA (LncRNA), might be key mediators of posttranscriptional gene expression/function in pathology of ischemic stroke [7] ; [8 … produced by intra-luminal occlusion of the right MCA using a silicone coated nylon (6-0) monofilament (Doccol Corporation, Redlands …
Cited by 3 Related articles All 4 versions

[HTML] strokeinfarct volume estimation in fixed tissue: Comparison of diffusion kurtosis imaging to diffusion weighted imaging and histology in a rodent MCAO model

V Bay, BF Kjølby, NK Iversen, IK Mikkelsen, M Ardalan… - PloS one, 2018 - journals.plos.org
… The fast kurtosis techniques have been validated against conventional DKI in an animal model of stroke [36] and have been shown to be contrast-to-noise efficient compared to conventional DKI [30] … [39] using a 4–0 reusable suture (4041PK5Re, Doccol Corporation, Sharon …
Related articles All 9 versions

[HTML] PAI-1 but Not PAI-2 Gene Deficiency Attenuates Ischemic Brain Injury After Experimental stroke

EV Griemert, KR Pelz, K Engelhard, MK Schäfer… - Translational stroke …, 2018 - Springer
… First, the time-dependent regulation of plasminogen activator system genes after stroke was exam- ined by quantitative PCR (qPCR) and then the … Brain ischemia was induced for 60 min by temporary MCAO using a silicone-coated 6–0 filament (6023; Doccol Corp., Redlands …
All 4 versions

A deficiency of the GluN2C subunit of the N-methyl-D-aspartate receptor is neuroprotective in a mouse model of ischemic stroke

A Holmes, N Zhou, DL Donahue, R Balsara… - Biochemical and …, 2018 - Elsevier
… A coated-tip suture (#602334, Doccol Corp., Sharon, MA) was inserted to occlude the middle carotid artery via the external carotid artery … brain specimens for analysis: (1) death before 24áh post-MCAO time point; (2) absence of any detectable ischemic infarct; (3) stroke in the …
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Time-of-day dependent neuronal injury after ischemic stroke: implication of circadian clock transcriptional factor bmal1 and survival kinase AKT

MC Beker, B Caglayan, E Yalcin, AB Caglayan… - Molecular …, 2018 - Springer
… A 7-0 silicon-coated nylon monofilament (701934PK5Re, Doccol; USA) was inserted through a small incision into the common carotid artery … For 30 min MCAo, tissue samples obtained from the ipsilateral to the stroke were collected for proteomics, planar surface immunoassay …
Cited by 7 Related articles All 3 versions

[HTML] Experimental Strokedifferentially affects discrete subpopulations of splenic macrophages

L McCulloch, A Alfieri, BW McColl - Frontiers in immunology, 2018 - ncbi.nlm.nih.gov
… Experimental stroke Model and Tissue Harvesting. Middle cerebral artery occlusion (MCAO) was performed under isoflourane anesthesia (with O 2 and N 2 O) by insertion of a 6-0 nylon monofilament with a 2 mm coated tip (210 µm diameter; Doccol, USA) through the external …
Related articles All 7 versions

Quantitative assessment of demyelination in ischemic Stroke in vivo using macromolecular proton fraction mapping

MY Khodanovich, AA Kisel, AE Akulov… - Journal of Cerebral …, 2018 - journals.sagepub.com
A recent MRI method, fast macromolecular proton fraction (MPF) mapping, was used to quantify demyelination in the transient middle cerebral artery occlusion (MC...
Transient left МСАО was achieved in 15 animals by inserting a nylon filament (diameter 0.185 mm, length 30 mm, diameter with coating 0.39 ± 0.02 mm, coating length 9–10 mm; Doccol, USA) to the origin of the artery for 1 h as described previously
Related articles All 3 versions

Sequential combined Treatment of Pifithrin-α and Posiphen Enhances Neurogenesis and Functional Recovery After stroke

F Turcato, P Kim, A Barnett, Y Jin… - Cell …, 2018 - journals.sagepub.com
Objective: Although cerebral ischemia can activate endogenous reparative processes, such as proliferation of endogenous neural stem cells (NSCs) in the subventr...
A nylon filament suture with a silicon coated tip (Doccol Co., Sharon, MA,  USA)  was  inserted  into  the  lECA  stump  and  further pushed along the lumen of the internal carotid artery while the clamp was released, and then the tie around lICA was tightened....
Related articles All 3 versions

Neuronal PirB upregulated in cerebral ischemia acts as an attractive theranostic target for ischemic stroke

J Wang, Y Zhang, J Xia, T Cai, J Du… - Journal of the …, 2018 - Am Heart Assoc
… probes for real‐time monitoring of ischemic stroke, and to deliver soluble PirB ectodomains by nanoliposomes to improve stroke model recovery … A 6‐0 nylon monofilament suture (Doccol Co., Redlands, CA) was inserted from the common carotid artery into the internal carotid …
Cited by 1 Related articles All 6 versions

Age of donor of human mesenchymal stem cells affects structural and functional recovery after cell therapy following ischaemic stroke

S Yamaguchi, N Horie, K Satoh… - Journal of Cerebral …, 2018 - journals.sagepub.com
Cell transplantation therapy offers great potential to improve impairments after stroke. However, the importance of donor age on therapeutic efficacy is unclear...
Transient middle cerebral artery occlusion was performed for 75 min with 4.0 nylon monofilament sutures coated with silicone (4039PK10; Doccol) as previously described...
Cited by 2 Related articles All 6 versions

Heat shock protein A12A encodes a novel prosurvival pathway during ischaemic stroke

Y Mao, Q Kong, R Li, X Zhang, Y Gui, Y Li, C Li… - … et Biophysica Acta (BBA …, 2018 - Elsevier
… Ischaemic stroke was induced by left middle cerebral artery occlusion (MCAO) for 1 h followed by blood reperfusion as we previously described … A 6–0 filament coated with silicon resin (Doccol Corp., Sharon, MA) was introduced into the left common carotid artery and advanced …
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[HTML] L-3-n-Butylphthalide reduces ischemic Strokeinjury and increases M2 microglial polarization

F Li, Q Ma, H Zhao, R Wang, Z Tao, Z Fan… - Metabolic brain …, 2018 - Springer
… of NBP on microglial polarization and inflammatory responses in the middle cerebral artery occlusion (MCAO) model of ischemic stroke … A silicone rubber-coated monofilament su- ture (Catalogue number: 701956PK5Re; Doccol Corporation, Sharon, MA, USA) was inserted into …
All 3 versions

Role of Steroid Therapy after Ischemic Strokeby n-Methyl-d-Aspartate Receptor Gene Regulation

AA Tameh, M Karimian, Z Zare-Dehghanani… - Journal of Strokeand …, 2018 - Elsevier
… Transient middle cerebral artery occlusion (tMCAO) was used to prepare experimental stroke as described previously … Then a silicon-coated monofilament (404356PK10Re, Doccol, Sharon, Massachusetts) introduced into the lumen of CCA and forwarded to internal carotid …
All 5 versions

High intensity exercise preconditioning provides differential protection against brain injury following experimental stroke

R Rezaei, S Nasoohi, A Haghparast, F Khodagholi… - Life sciences, 2018 - Elsevier
… Intraluminal middle cerebral artery occlusion (MCAO) was applied to induce ischemic stroke, as described previously [26]. Briefly, animals were anesthetized with chloral hydrate (400 mg/kg, ip) and a 4–0 silicon-coated nylon suture (OD: 0.35 mm; Doccol, USA) was advanced …
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[HTML] Transcriptomic analysis of neuregulin-1 regulated genes following ischemic strokeby computational identification of promoter binding sites: A role for the ETS …

MC Surles-Zeigler, Y Li, TJ Distel, H Omotayo, S Ge… - PloS one, 2018 - journals.plos.org
… These findings could support the development of clinical studies using NRG1 for the treatment of patients with acute stroke … Briefly, a 4 cm length 4–0 surgical monofilament nylon suture coated with silicon (Doccol Corp., Sharon, MA, diameter 0.37 mm, length 2.3–2.5 mm) was …
Related articles All 7 versions

Exacerbated brain edema in a rat streptozotocin model of hyperglycemic ischemic stroke: Evidence for involvement of blood–brain barrier Na–K–Cl cotransport and …

NY Yuen, OV Chechneva, YJ Chen… - Journal of Cerebral …, 2018 - journals.sagepub.com
Cerebral edema is exacerbated in diabetic ischemic stroke through poorly understood mechanisms. We showed previously that blood–brain barrier (BBB) Na–K–Cl cotr...
(Doccol MCAO suture was used for inducing the stroke model)
Cited by 1 Related articles All 3 versions

Post-ischaemic administration of the murine Canakinumab-surrogate antibody improves outcome in experimental stroke

L Liberale, C Diaz-Cañestro, NR Bonetti… - European heart …, 2018 - academic.oup.com
… Post-ischaemic administration of the murine Canakinumab-surrogate antibody improves outcome in experimental stroke … Despite the success of the trial, incidence of stroke was not reduced likely due to the low number of events and the relatively young age of patients enrolled …
Ischaemia was induced by inserting a 6-0 silicone-coated filament (Doccol Corporation, Sharon, MA, USA) into the common carotid artery until the origin of the left middle cerebral artery after the dissection of common, internal and external carotid arteries.
Cited by 2 Related articles All 4 versions

Effect of a multinutrient intervention after ischemic Strokein female C57Bl/6 mice

M Wiesmann, NM Timmer, B Zinnhardt… - Journal of …, 2018 - Wiley Online Library
… 30 min) occlusion of the right middle cerebral artery (tMCAo), thus mimicking one of the most common types of ischemic stroke in patients … Next, a 7-0 monofilament (tip diameter 190–200 μm, coating length 2–3 mm, 70SPRePK5, Doccol Corp., Sharon, MA, USA) was inserted in...
Cited by 2 Related articles All 5 versions

Inhibition of the potassium channel Kv1. 3 reduces infarction and inflammation in ischemic stroke

YJ Chen, HM Nguyen, I Maezawa… - Annals of clinical and …, 2018 - Wiley Online Library
… We therefore hypothesized that Kv1.3 blockers could be useful for ameliorating pathology in ischemic stroke, where activated microglia significantly contribute to … monofilament with a tip diameter of 0.21 ± 0.02 mm for mice and of 0.43 ± 0.02 mm for rats (Doccol Corp.) inserted …
Cited by 1 Related articles All 5 versions

Metallothionein I as a direct link between therapeutic hematopoietic stem/progenitor cells and cerebral protection in stroke

HK Smith, S Omura, SA Vital, F Becker… - The FASEB …, 2018 - fasebj.org
… after I/RI, coupled with decreasing mortality, infarct volume (IV), and neurologic score (NS), when administered as late as 24 h after stroke … 7.5 mg/kg), and middle cerebral artery occlusion was occluded for 30 min using a 6-nylon intraluminal filament (Doccol, Sharon, MA, USA …
Related articles All 4 versions

Calcium-dependent reactive oxygen formation and blood-brain barrier breakdown by NOX5 limits post-reperfusion outcome in stroke

AI Casas, PWM Kleikers, E Geuss, F Langhauser… - bioRxiv, 2018 - biorxiv.org
Page 1. 1 Calcium-dependent reactive oxygen formation and blood-brain barrier 1 breakdown by NOX5 limits post-reperfusion outcome in stroke 2 … 15 Short title: Ca2+-dependent ROS formation by NOX5 explains BBB breakdown and 16 worse outcome in stroke 17 18 …
A silicon rubber-coated 6.0 nylon monofilament (602312PK10, Doccol Corporation, Sharon, MA, USA) for mice was inserted through a small incision into the common carotid artery and advanced into the internal carotid artery  until  a  resistance  is  felt....
All 2 versions

HSPA 12B promotes functional recovery after ischaemic Strokethrough an eNOS‐dependent mechanism

Y Zhao, C Liu, J Liu, Q Kong, Y Mao… - Journal of cellular …, 2018 - Wiley Online Library
… Ischaemic stroke. Ischaemic stroke was induced by transient middle cerebral artery occlusion for 60 min … A 6‐0 filament coated with silicon resin (Doccol Corp. Sharon, MA) was introduced into the left common carotid artery and advanced 11 mm to begin ischaemia …
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Biodegradation of ECM hydrogel promotes endogenous brain tissue restoration in a rat model of stroke

H Ghuman, C Mauney, J Donnelly, AR Massensini… - Acta Biomaterialia, 2018 - Elsevier
… For transient intraluminal right middle cerebral artery (MCA) occlusion, a rat model of stroke, a 5-0 silicone rubber-coated monofilament (diameter 0.12 mm, length 30 mm, tip coating at 0.35 mm for 5-6 mm, Doccol, USA) was advanced to the ostium of the MCA in the circle of …
All 2 versions

Granulocyte-colony stimulating factor protects against endoplasmic reticulum stress in an experimental model of stroke

JM Menzie-Suderam, P Mohammad-Gharibani, J Modi… - Brain research, 2018 - Elsevier
… Elsevier. Brain Research. Volume 1682, 1 March 2018, Pages 1-13. Brain Research. Research report. Granulocyte-colony stimulating factor protects against endoplasmic reticulum stress in an experimental model of stroke … 2. Results. 2.1. stroke surgery and cerebral blood flow …
A 4-0 monofilament nylon suture coated with silicon (Doccol Co., NM, USA) was inserted through an incision in the external carotid artery, gently advanced into the internal carotid artery, and positioned approximately 18–22 mm from the carotid bifurcation.
Cited by 2 Related articles All 3 versions

Chemical Sympathectomy, but not Adrenergic Blockade, Improves StrokeOutcome

D Zierath, T Olmstead, A Stults, A Shen, A Kunze… - Journal of Strokeand …, 2018 - Elsevier
… After stroke/intervention, the median blood pressure value for each session was used for analyses … A monofilament suture (Doccol; 4.0) was inserted into the common carotid artery and advanced into the internal carotid artery to block the origin of the middle cerebral artery …
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[HTML] Immunosignals of Oligodendrocyte Markers and Myelin-Associated Proteins Are Critically Affected after Experimental Strokein Wild-Type and Alzheimer …

D Michalski, AL Keck, J Grosche, H Martens… - Frontiers in cellular …, 2018 - frontiersin.org
… structures during stroke evolution, representing a prerequisite for more elaborated neuroprotective and restorative strategies in acute stroke … Thereby, a standardized silicon-coated 6-0 monofilament (Doccol Corporation, Redlands, CA, United States) was moved forward from …
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Immune responses in stroke: how the immune system contributes to damage and healing after Strokeand how this knowledge could be translated to better cures?

A Rayasam, M Hsu, JA Kijak, L Kissel… - …, 2018 - Wiley Online Library
Page 1. Immune responses in stroke: how the immune system contributes to damage and healing after stroke and how this knowledge could be translated to better cures … Summary stroke is one of the leading causes of death and disability worldwide …
A standardized polyamide resin glue‐coated 6·0 nylon monofilament (6021910; Doccol Corp.,Sharon, MA) was introduced into the ECA lumen, and then advanced ~ 9–9·5 mm in the ICA lumen to block middle cerebral artery blood flow.
Cited by 4 Related articles All 3 versions

Interferon regulatory factor 4/5 signaling impacts on microglial activation after ischemic Strokein mice

A Al Mamun, A Chauhan, H Yu, Y Xu… - European Journal of …, 2018 - Wiley Online Library
… inserting a 6.0-mm monofilament (Doccol Corp, Redlands, CA, USA) into the right internal carotid artery 6 mm from the internal carotid/pterygopalatine artery bifurcation via an external carotid artery stump. Regional cerebral blood flow was measured in all stroke animals using …
Cited by 5 Related articles All 4 versions

[HTML] Targeted intracerebral delivery of the anti-inflammatory cytokine IL13 promotes alternative activation of both microglia and macrophages after stroke

SH Taj, D Le Blon, C Hoornaert… - Journal of …, 2018 - jneuroinflammation.biomedcentral …
… 1 A time line of the experimental protocol. stroke was induced in all mice via the middle cerebral artery occlusion (MCAO) … A silicon rubber-coated filament with a tip diameter of 170 μm (7017PK5Re, Doccol Corporation, Sharon, MA, USA) was inserted into the ICA …
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Rat cranial bone-derived mesenchymal stem cell transplantation promotes functional recovery in ischemic Strokemodel rats

M Abiko, T Mitsuhara, T Okazaki, T Imura… - Stem cells and …, 2018 - liebertpub.com
… a microscope. A 4-0 nylon monofilament suture coated with silicone (403745PK10; Doccol Corporation) was inserted through the external carotid artery into the internal carotid … ctional re co very in isch emic stroke model ra ts (D OI: 1 0 .10 89 /scd .20 1 8 .00 22 ) This paper h …
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[HTML] CCR2-dependent monocytes/macrophages exacerbate acute brain injury but promote functional recovery after ischemic Strokein mice

W Fang, X Zhai, D Han, X Xiong, T Wang, X Zeng… - Theranostics, 2018 - ncbi.nlm.nih.gov
… Focal cerebral ischemia was induced by transient MCA occlusion for 45 min by inserting a silicone-coated 6-0 monofilament (Doccol Corp, Redlands, CA, USA) into the left CCA to block the MCA, as we … Brain atrophy at 14 or 28 days after stroke was measured with Nissl staining …
Cited by 1 Related articles

… by N-Acetyl Lysyltyrosylcysteine Amide Reduces Oxidative Stress–Mediated Inflammation, Neuronal Damage, and Neural Stem Cell Injury in a Murine Model of stroke

G Yu, Y Liang, S Zheng, H Zhang - Journal of Pharmacology and …, 2018 - ASPET
...In brief, a 6-0 nylon monofilament suture coated with silicon-rubber (Doccol, Sharon, MA) was inserted into the left internal carotid artery and advanced approximately 10 mm distal to the carotid bifurcation to occlude the origin of the middle cerebral artery. The thread was carefully ~~~
Cited by 2 Related articles All 4 versions

Inhibition of microRNA-210 suppresses pro-inflammatory response and reduces acute brain injury of ischemic Strokein mice

L Huang, Q Ma, Y Li, B Li, L Zhang - Experimental neurology, 2018 - Elsevier
… phase of stroke in adult mice, suggesting a novel therapeutic strategy of the miR-210 blockade in the treatment of acute ischemic stroke … A 6-0 nylon monofilament coated with silicon rubber (Doccol) was introduced into the left internal carotid artery through the external carotid …
Cited by 7 Related articles All 4 versions

[HTML] IL-33 modulates inflammatory brain injury but exacerbates systemic immunosuppression following ischemic stroke

SR Zhang, M Piepke, HX Chu, BRS Broughton… - JCI …, 2018 - Am Soc Clin Investig
… IL-33 modulates inflammatory brain injury but exacerbates systemic immunosuppression following ischemic stroke … hours. Supplementary antibiotics (gentamicin and ampicillin) mitigated these systemic effects of IL-33 after stroke …
Briefly, the right proximal common carotid artery was clamped, and a 6-0 nylon monofilament with silicone-coated tip (Doccol Corp.) was inserted and gently advanced into the distal internal carotid artery, 11–12 mm distal to the carotid bifurcation, occluding the MCA at the junction of the circle of Willis.
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[HTML] Potential benefits of mesenchymal stem cells and electroacupuncture on the trophic factors associated with neurogenesis in mice with ischemic stroke

YR Kim, SM Ahn, ME Pak, HJ Lee, DH Jung, YI Shin… - Scientific reports, 2018 - nature.com
… Article | Open. Potential benefits of mesenchymal stem cells and electroacupuncture on the trophic factors associated with neurogenesis in mice with ischemic stroke … Results. Effects of mBMSC and EA treatment on post-stroke behavior …
Focal cerebral ischemia was induced in the middle cerebral artery through the internal carotid artery by inserting the filament (Doccol Corporation, Sharon, MA 02067–2427, USA) into the common carotid artery.
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Simvastatin blocks soluble SSAO/VAP-1 release in experimental models of cerebral ischemia: Possible benefits for stroke-induced inflammation control

P Sun, M Hernandez-Guillamón… - … et Biophysica Acta (BBA …, 2018 - Elsevier
… described, treatment with simvastatin reduced the infarct lesion by 44.7% at 48 h after cerebral ischemia in a rat embolic model of stroke [10] … A silicone-coated nylon monofilament (Doccol Corporation, MA, USA, reference number: 403723PK10) was inserted to occlude the MCA …
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Neuroprotective effect of the group III mGlu receptor agonist ACPT-I after ischemic strokein rats with essential hypertension

H Domin, Ł Przykaza, E Kozniewska… - Progress in Neuro …, 2018 - Elsevier
… As previously discussed, preclinical studies are typically performed with healthy animals, whereas stroke patients predominately exhibit comorbidities, such as … The ø 37 μm silicone-coated filament (model 4037Pk10; Doccol Co., Redlands, CA, USA) attached to 3-0 surgical …
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A hemorrhagic transformation model of mechanical Stroketherapy with acute hyperglycemia in mice

D Couret, S Bourane, A Catan, B Nativel… - Journal of …, 2018 - Wiley Online Library
… To our knowledge, no experimental study investigated the effect of acute HG on stroke severity according to time of ischemia … Cerebral ischemia was achieved by intraluminal MCAO by introducing a 7-0 silicon-coated monofilament (Doccol Corporation, Sharon, MA) through the...

[HTML] Post-strokemRNA expression profile of MMPs: effect of genetic deletion of MMP-12

KR Nalamolu, B Chelluboina, IB Magruder… - Strokeand Vascular …, 2018 - svn.bmj.com
 Post-stroke mRNA expression profile of MMPs: effect of genetic deletion of MMP-12. Koteswara Rao Nalamolu1,; Bharath Chelluboina …
After the animals reached a weight of ~23.5 g, they were subjected to right MCAO procedure by using a silicone rubber–coated monofilament suture (Doccol, California, USA). Briefly, a ventral midline incision (~15–20 mm) was made in the neck and the right common carotid, internal carotid and external carotid arteries were surgically exposed.
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Chinese medicine Tongxinluo capsule alleviates cerebral microcirculatory disturbances in ischemic Strokeby modulating vascular endothelial function and inhibiting …

S Liu, C Wei, N Kang, Q He, J Liang, H Wang… - …, 2018 - Wiley Online Library
… Ischemic stroke model was induced by pMCAO as previously described.[13] Briefly, mice were anesthetized with 3.5% chloral hydrate (350 mg/kg … side of the left CCA with a 6-0 nylon suture, a 6-0 silicon-coated monofilament suture (602156PK5Re; Doccol Corporation, Sharon …
Cited by 1 Related articles All 3 versions

Curcumin protects neural cells against ischemic injury in N2a cells and mouse brain with ischemic stroke

CJ Xie, AP Gu, J Cai, Y Wu, RC Chen - Brain and behavior, 2018 - Wiley Online Library
… However, the exact mechanisms underlying the protective effects of curcumin against ischemic stroke are still not fully understood … by intraluminal occlusion of the right middle cerebral artery using a silicone coated nylon (6.0) monofilament (Doccol Corporation, Redlands, CA …
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Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: implications for cerebral ischemic stroke

B Han, Y Zhang, Y Zhang, Y Bai, X Chen, R Huang… - Autophagy, 2018 - Taylor & Francis
Page 1. RESEARCH PAPER - BASIC SCIENCE Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: implications for cerebral ischemic stroke … However, the potential role of circRNAs in stroke remains largely unknown …
Next, a silicone-rubber-coated 6–0 nylon filament (Doccol, 602356PK5Re) was inserted into the ECA and advanced over 9–10 mm to the ...
Cited by 1 All 3 versions

The neuroprotective effects of flaxseed oil supplementation on functional motor recovery in a model of ischemic brain stroke: Upregulation of BDNF and GDNF

A Bagheri, S Talei, N Hassanzadeh, T Mokhtari… - Acta Medica …, 2018 - acta.tums.ac.ir
… Page 2. The neuroprotective effects of flaxseed oil in stroke model 786 Acta Medica Iranica, Vol … Then, internal carotid artery (ICA) was carefully dissected to conduct an intraluminal 4-0 nylon monofilament (Doccol Co., USA) to block the origin of the medial carotid artery (MCA) …
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Protective Effects of Spatholobi Caulis Extract on Neuronal Damage and Focal Ischemic stroke/Reperfusion Injury

HR Park, H Lee, JJ Lee, NH Yim, MJ Gu, JY Ma - Molecular neurobiology, 2018 - Springer
… The focal ischemic stroke by transient MCAO-reperfusion model was generated as described previously [20, 21] … A 4-0 monofilament nylon suture (2–3 mm silicon coating length, 0.39 mm tip diameter; Doccol Corporation, MA, USA) was inserted into the internal carotid arteries …
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MiR-298 Exacerbates Ischemia/Reperfusion Injury Following Ischemic strokeby Targeting Act1

H Sun, D Zhong, C Wang, Y Sun, J Zhao… - Cellular Physiology and …, 2018 - karger.com
… The middle cerebral artery occlusion (MCAO) model of ischemic stroke was established as previously described [13, 14] … This was followed by a small incision to the ECA artery between the permanent and temporary sutures and insertion of a Doccol suture (0.21 mm in diameter …
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Therapeutic Potential of a Combination of Electroacupuncture and TrkB-Expressing Mesenchymal Stem Cells for Ischemic stroke

SM Ahn, YR Kim, YI Shin, KT Ha, SY Lee, HK Shin… - Molecular …, 2018 - Springer
… EA could induce the grafted MSCs to differentiate into mature neuron-like cells, thus improving functional recovery from ischemic stroke … Middle cerebral artery occlusion (MCAO) was induced by a silicon rubber-coated 7-0 monofilament (Doccol Corporation, Sharon, MA, USA …
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[PDF] How to Modify the Forced Running Wheel for Ischemic StrokeRehabilitation in Rats

CC Chen, CP Chang - Neuropsychiatry (London), 2018 - jneuropsychiatry.org
… Then, a 4-0 monofilament nylon suture (Doccol Corporation, Redlands, CA, USA) was inserted into the ECA and then into the ICA until the middle cerebral artery (MCA) was blocked to induce a cerebral ischemic stroke. Reperfusion …

Neuroprotective Effects of Oxytocin Hormone after an Experimental StrokeModel and the Possible Role of Calpain-1

SE Moghadam, AA Tameh, Z Vahidinia… - Journal of strokeand …, 2018 - Elsevier
… However, the neuroprotective effects of OT on cerebral stroke and related signaling pathways are not completely understood … The nylon monofilament with a silicone-coated tip (Doccol, USA) entered into the artery lumen and moved slowly forward until a sudden decrease …
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strokepromotes survival of nearby transplanted neural stem cells by decreasing their activation of caspase 3 while not affecting their differentiation

N Kosi, I Alić, I Salamon, D Mitrečić - Neuroscience letters, 2018 - Elsevier
… Surprisingly, stroke supports survival of NSCs in striatum by reducing activation of Casp3, but it has no influence on … Following ventral neck surgery and blood vessels preparation, intraluminal filament (Doccol Company, Sharon, MA, USA) was inserted through common carotid …
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[BOOK] Role of MicroRNAs in Preconditioning-mediated Ischemic Tolerance and Neuroprotection After stroke

MS Lopez - 2018 - search.proquest.com
Page 1. Role of microRNAs in preconditioning-mediated ischemic tolerance and neuroprotection after stroke By Mary Susan Lopez … 10745095 2018 Page 3. i ABSTRACT Ischemic stroke is a devastating disease process that results in over six million deaths per year worldwide …
(Doccol MCAO suture was used for inducing the stroke model)
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[HTML] A Tail-Worn Sensor-Equipped Heart Rate Measurement Apparatus for Ischemic StrokePrevention

CC Chen, CP Chang - Neuropsychiatry, 2018 - jneuropsychiatry.org
… A filament (a 4-0 nylon suture with a blunted tip, 0.37 mm in diameter; Doccol Corporation, USA) coated with poly-Llysine was inserted into the right ECA … An inclined plane test is a quantitative measure of a rat's motor function recovery after an ischemic stroke …
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The Role of Alpha-Lipoic Acid in the Pathomechanism of Acute Ischemic stroke

Q Wang, C Lv, Y Sun, X Han, S Wang, Z Mao… - Cellular Physiology and …, 2018 - karger.com
… factor (NF)-κB and microglia activation has been shown to play an important role in cerebral injury induced by experimental stroke [14 … A silicon-coated nylon monofilament (tip diameter: 0.37 ± 0.02 mm, Doccol, MA, USA) was inserted into the middle cerebral artery as described …
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Effects of CD4+ T cells on tissue remodeling and autoreactive responses after experimental stroke

T Zhang - 2018 - refubium.fu-berlin.de
… Effects of CD4+ T cells on tissue remodeling and autoreactive responses after experimental stroke zur Erlangung des akademischen Grades Doctor of Philosophy (PhD) … 3 2.1 stroke ..... 3 …
Silicon rubber-coated monofilament
with a diameter of 0.19 ± 0.01 mm (Doccol) was introduced into the common carotid artery,
advanced along the internal carotid artery towards the origin of the MCA, and either withdrawn
immediately to allow instant reperfusion (sham operation) or left there for 60 min.

[PDF] The role of blood-based biomarkers in ischemic stroke

S Tiedt - 2018 - edoc.ub.uni-muenchen.de
… ünchen ischemic stroke Page 2. II … 970 stroke is the leading cause of long-term disability and the second most common cause of death worldwide with ≈80% of cases attributed to ischemia.1 Currently, the diagnosis of ischemic stroke (IS) on hospital arrival is often reduced to …
a 2 mm silicon-coated filament (Doccol, #701912PKRe) was inserted into the internal carotid  artery and MCA occlusion was confirmed by a corresponding decrease in blood flow (i.e., a decrease in the laser Doppler flow signal to less than 20 % of baseline). 
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Neuroprotective and Neuroregenerative Effect of Secreted Factors from Human Adipose Stem Cells in a Rat StrokeModel

서한길 - 2018 - s-space.snu.ac.kr
… effect and experiment 2 to investigate the long-term neuroregenerative effect of study interventions in a rat ischemic stroke model (Fig 1) … artery. Thereafter, a 0.39 mm silicon coated monofilament nylon suture (Doccol, Sharon …
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INVESTIGATIONS OF INTERLEUKIN-1 ALPHA AS A NOVEL StrokeTHERAPY IN EXPERIMENTAL ISCHEMIC stroke

KE Salmeron - 2018 - uknowledge.uky.edu
… 2018 INVESTIGATIONS OF INTERLEUKIN-1 ALPHA AS A NOVEL stroke THERAPY IN EXPERIMENTAL ISCHEMIC stroke … Although rapid recognition and prompt treatment have dropped mortality rates, most stroke survivors are left with permanent disability …
The internal  carotid  artery  and  the  pterygopalatine  artery  were  temporarily  ligated.  A  6-0  monofilament  (Doccol,  Sharon,  MA,  USA)  was  introduced  into  the  internal  carotid  artery  via  an  incision  in  the  common  carotid  artery. 

THE ROLE OF SIRTUIN-2 IN ISCHAEMIC stroke-INDUCED NEURONAL CELL DEATH

DSHETAI WAI - 2018 - scholarbank.nus.edu.sg
Page 1. THE ROLE OF SIRTUIN-2 IN ISCHAEMIC stroke-INDUCED NEURONAL CELL DEATH DAVID SHE TAI WAI (B.Sc … List of Figures viii List of Abbreviations x Chapter 1: Introduction 1 1.1 stroke as the leading cause of death 1 1.2 Pathophysiology of ischaemic stroke 2 …
The external carotid artery (ECA) was cut and a 6-0 monofilament with the tip blunted and coated with silicone rubber (0.21-0.23mm in diameter, Doccol Corporation, Sharon, MA, USA) was gently introduced into the ICA through the ECA.
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Neuroprotective effect of glucagon-like peptide-1 receptor agonist is independent of glycaemia normalization in type two diabetic rats

I Filchenko, A Simanenkova, S Chefu… - Diabetes and …, 2018 - journals.sagepub.com
Objective: Stroke is a severe complication of type 2 diabetes mellitus. Glucagon-like peptide-1 receptor agonists have been shown to have a neuroprotective effe...
On the seventh day, blood glucose levels were analysed, and focal cerebral ischaemia was induced by filament occlusion of the left middle cerebral artery (MCA) (Doccol Corporation, USA) for 30 min under anaesthesia with 430 mg/kg chloral hydrate as described previously.

Remote Limb Ischemic Conditioning during Cerebral Ischemia Reduces Infarct Size through Enhanced Collateral Circulation in Murine Focal Cerebral Ischemia

K Kitagawa, M Saitoh, K Ishizuka, S Shimizu - Journal of Strokeand …, 2018 - Elsevier
… In terms of clinical utility, per-RIC and post-RIC are feasible and clinical trials of RIC for acute ischemic stroke are either … Re L45 PK5; Doccol Corporation, Sharon, MA) was introduced through the carotid bifurcation into the left internal carotid artery (ICA) and advanced by 10 mm …
Cited by 1 Related articles All 5 versions

[HTML] Hydrogen inhalation improves mouse neurological outcomes after cerebral ischemia/reperfusion independent of anti-necroptosis

JL Huang, WW Liu, XJ Sun - Medical gas research, 2018 - ncbi.nlm.nih.gov
… is termed “necroptosis”.8 Currently, studies have indicated that necroptosis play an important role in the pathogenesis of ischemic stroke, hemorrhagic stroke, and cerebral … Then, a monofilament suture (Doccol, Sharon, MA, USA) was inserted into the internal carotid artery (ICA) …
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Treatment with Uric Acid Reduces Infarct and Improves Neurologic Function in Female Mice After Transient Cerebral Ischemia

N Dhanesha, E Vázquez-Rosa… - Journal of strokeand …, 2018 - strokejournal.org
… Genetic ablation of extra domain a of fibronectin in hypercholesterolemic mice improves stroke outcome by reducing thrombo-inflammation … midline incision, the right common carotid artery (CA) was temporarily clamped and a 6.0 siliconized filament (Doccol Corporation, Sharon …
Cited by 2 Related articles All 3 versions

[HTML] The CD40/CD40L system regulates rat cerebral microvasculature after focal ischemia/reperfusion via the mTOR/S6K signaling pathway

RH Jiang, XQ Xu, CJ Wu, SS Lu, QQ Zu… - Neurological …, 2018 - Taylor & Francis
… Focal cerebral ischemia was induced by transient monofilament (4041PK10, Doccol, Redlands, CA, USA) occlusion of the right middle cerebral artery occlusion (MCAO) for 60 min … stroke. 1993;24:117–121.[Crossref], [PubMed], [Web of Science ®] [Google Scholar]] …
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Using the behavioral flexibility operant task to detect long-term deficits in rats following middle cerebral artery occlusion

MMM Andrews, S Peruzzaro, S Raupp, J Wilks… - Behavioural brain …, 2019 - Elsevier
… [13]. This task is inexpensive and easy to administer and translates nicely to cognitive flexibility deficits observed in human stroke patients … clips were placed on the common and internal carotid arteries and a silicon coated nylon filament (0.37 mm in diameter; Doccol, MA) was …
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Silencing VEGF-B Diminishes the Neuroprotective Effect of Candesartan Treatment After Experimental Focal Cerebral Ischemia

T Ishrat, S Soliman, W Eldahshan, B Pillai… - Neurochemical …, 2018 - Springer
… We hypothesized that silencing VEGF-B would diminish the neurovascular pro- tection by candesartan after ischemic stroke … Temporary middle cerebral artery occlusion (MCAO) was achieved using 4–0 silicon- coated nylon suture (Doccol, Sharon, MA), advanced into the …
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[PDF] FISH-OIL PRECONDITIONING MODULATES PLASMA MCP-1 AND TIMP-1 LEVELS AFTER EXPERIMENTAL INDUCED TRANSIENT CEREBRAL ISCHEMIA

A HUȚANU, E Horvath, A ORĂDAN, S VOIDĂZAN… - …, 2018 - revistafarmacia.ro
… 603 leading to amplification of detrimental conditions in ischemic stroke [8]. Monocyte chemoattractant protein-1 (MCP-1/CCL2) chemokine ligand-2 involved in monocyte … The body temperature was maintained constant at 37°C with a heating pad (Doccol Corporation, USA) …

Upregulation of miR-215 exerts neuroprotection effects against ischemic injury via negative regulation of Act1/IL-17RA signaling

H Sun, D Zhong, J Jin, Q Liu, H Wang, G Li - Neuroscience letters, 2018 - Elsevier
… The middle cerebral artery occlusion (MCAO) model of ischemic stroke was established as follows … This was followed by a small incision to the ECA artery between the permanent and temporary sutures and insertion of a Doccol suture (0.21 mm in diameter) into the ICA about 10 …
Cited by 1 Related articles All 4 versions

Spin‐lock imaging of early tissue pH changes in ischemic rat brain

Z Zu, A Afzal, H Li, J Xie, JC Gore - NMR in Biomedicine, 2018 - Wiley Online Library
… A 30 mm, silicon‐coated, 4‐0 nylon suture (Doccol, Redlands, CA, USA) was routed into the left internal carotid artery and advanced until it occluded the … ROI within the stroke in each rat obtained at 0.5‐1 h were selected in the left hemisphere with ΔR 1ρ values more than one …
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Selective Brain Hypothermia Augmenting Neuroprotective Effects of Decompressive Craniectomy for Permanent Middle Cerebral Artery Infarction in a Rat Model

J Park, JH Kim, K Suk, HS Han, B Ohk… - World …, 2018 - worldneurosurgery.org
… 2-5 In the meantime, the neuroprotective properties of therapeutic hypothermia have already been demonstrated in various animal stroke models and some clinical studies. 6-10 Yet, the … 6 (Doccol Co.; Albuquerque, NM, USA) was then inserted through an arteriotomy of the …
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[HTML] Berberine confers neuroprotection in coping with focal cerebral ischemia by targeting inflammatory cytokines

SN Maleki, N Aboutaleb, F Souri - Journal of chemical neuroanatomy, 2018 - Elsevier
… Berberine might be used as a potential therapeutic agent to reduce inflammation and neuronal demise after ischemic stroke. 2. Materials and methods. 2.1 … Silicon rubber-coated monofilament for MCAO model was purchased from Doccol company (Philadelphia, PA, USA) …
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The Long-Term Outcome Comparison of Different Time-Delayed Kallikrein Treatments in a Mouse Cerebral Ischemic Model

Y Ni, K Cai, Y Hu, C Wang, Y Zhang, H Huang… - Stem cells …, 2018 - hindawi.com
… the present study, we compared the effects of delayed kallikrein treatment starting at 8 h, 24 h, and 36 h after stroke onset in … A 6–0 nylon suture with silicon coating (Doccol Corporation, Redlands, CA) was inserted into the internal carotid artery through the external carotid artery …
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[HTML] Genetic and pharmacological inhibition of Cdk1 provides neuroprotection towards ischemic neuronal death

Q Marlier, F Jibassia, S Verteneuil, J Linden… - Cell death …, 2018 - nature.com
… Administration of tissues plasminogen activator is currently the only treatment used to reduce damage from stroke with medium efficacy 1 . Understanding the molecular mechanisms underlying stroke pathophysiology is critical to develop more effective therapies …
A slight hole was made between both holes in the common carotid artery to allow insertion of a 6-0 coated monofilament (Doccol), which was moved from the common carotid artery through the internal carotid artery up to the level of the middle cerebral artery (10–11 mm).
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Prevention of the Severity of Post-ischemic Inflammation and Brain Damage by Simultaneous Knockdown of Toll-like Receptors 2 and 4

KR Nalamolu, NJ Smith, B Chelluboina… - Neuroscience, 2018 - Elsevier
… Animals that did not show post-stroke symptoms after MCAO procedure was excluded from the study … Rats subjected to a 2-h transient MCAO with a monofilament suture (Doccol Corporation, USA) under isoflurane anesthesia as described earlier (Chelluboina et al., 2015) …
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Whole body vibration therapy after ischemia reduces brain damage in reproductively senescent female rats

A Raval, M Schatz, P Bhattacharya, N d'Adesky… - International journal of …, 2018 - mdpi.com
… Previous Article in Journal TPS Genes Silencing Alters Constitutive Indirect and Direct Defense in Tomato. Previous Article in Special Issue Effect of Inhibition of DNA Methylation Combined with Task-Specific Training on Chronic stroke Recovery …
tMCAO was achieved by intraluminal suture. A 30-mm-long 3-0 nylon monofilament suture coated with silicone (Doccol) and was placed 19–20 mm into the internal carotid artery to occlude the ostium of the MCA.
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Repression of the Glucocorticoid Receptor Aggravates Acute Ischemic Brain Injuries in Adult Mice

Y Li, L Huang, Q Ma, K Concepcion, M Song… - International journal of …, 2018 - mdpi.com
… Create a SciFeed alert for new publications. With following keywords. GR. MR. GR siRNA. ischemic stroke. MCAO. inflammation. BDNF/TrkB. By following authors. Yong Li. Lei Huang. Qingyi Ma. Katherine R. Concepcion. Minwoo A …
A 6-0 nylon monofilament coated with silicon rubber (Doccol) was introduced into the left internal carotid artery through the external carotid stump to occlude the origin of the middle cerebral artery and block blood flow to the striatum and cortex.
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Transplantation of feeder‐free human induced pluripotent stem cell–derived cortical neuron progenitors in adult male Wistar rats with focal brain ischemia

Y Hermanto, T Sunohara, A Faried… - Journal of …, 2018 - Wiley Online Library
… The government agency addressed several issues on the clinical translation of cell therapy in stroke … A 5‐0 silicone‐coated nylon thread (Doccol Co., MA, USA) was inserted into the right internal carotid artery through a small incision in the common carotid artery toward the …
Cited by 2 Related articles All 4 versions

Ginkgolide K Promotes Angiogenesis in a middle cerebral artery occlusion mouse model via activating JAK2/STAT3 Pathway

M Chen, W Zou, M Chen, L Cao, J Ding, W Xiao… - European journal of …, 2018 - Elsevier
… In general, the limited researches about GK are its anti-oxidative stress and neuroprotective effect on acute ischemic stroke, the long-term … The right MCA was occluded by inserting an intraluminal silicone coating filament (6–0 nylon, 6023PK, Doccol Corp, CA, USA) through the …
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[HTML] Mild Therapeutic Hypothermia Protects the Brain from Ischemia/Reperfusion Injury through Upregulation of iASPP

X Liu, S Wen, S Zhao, F Yan, S Zhao, D Wu… - Aging and …, 2018 - ncbi.nlm.nih.gov
… Right MCAO was performed by inserting a 7-0 nylon monofilament (Doccol Corporation, Sharon, MA, USA) into the internal carotid artery … Scores ranged from 0 in healthy animals to a maximum 10 in stroke animals that failed in all tasks …
Cited by 2 Related articles All 6 versions

Inhibition of the Epigenetic Regulator REST Ameliorates Ischemic Brain Injury

KC Morris-Blanco, TH Kim, MJ Bertogliat… - Molecular …, 2018 - Springer
… We also showed that a lncRNA called FosDT induced after stroke plays an essential role in scaffolding REST, coREST, and Sin3A … Laboratories) under isoflurane anesthesia by an intraluminal suture method using a 6-0 silicon-coated monofilament (Doccol Corporation) as...

[HTML] [18F]DPA-714 PET imaging shows immunomodulatory effect of intravenous administration of bone marrow stromal cells after transient focal ischemia

C Tan, S Zhao, K Higashikawa, Z Wang, M Kawabori… - EJNMMI research, 2018 - Springer
… a TSPO ligand [18F]DPA-714 PET/CT system in the present study, we aim to investigate the relationship between stroke and inflammation … A silicon rubber-coated monofilament with a tip coating diameter of 0.37 mm (Doccol Corp., Redlands, CA, USA) was inserted into the right …
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Ischemic damage and early inflammatory infiltration are different in the core and penumbra lesions of rat brain after transient focal cerebral ischemia

E Horváth, A Huțanu, L Chiriac, M Dobreanu… - Journal of …, 2018 - Elsevier
… al., 2010). Thus, the inflammatory process in stroke cannot be categorized as either exclusively beneficial or detrimental. Study … temperature recording. Body temperature was maintained with a heating pad (Doccol Corp.). Two …
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Dabigatran reduces endothelial permeability through inhibition of thrombin-induced cytoskeleton reorganization

HJ Choi, NE Kim, J Kim, S An, SH Yang, J Ha, S Cho… - Thrombosis research, 2018 - Elsevier
… We performed all experimental procedures according to Animal Research: Reporting for In Vivo Experiments (ARRIVE) [17] and stroke Therapy Academic … A commercially available 4–0 fine silicon rubber-coated nylon thread (Doccol Co., Sharon, MA, USA) was inserted after …
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[HTML] Effect of laser Doppler flowmetry and occlusion time on outcome variability and mortality in rat middle cerebral artery occlusion: inconclusive results

E Ingberg, H Dock, E Theodorsson… - BMC …, 2018 - bmcneurosci.biomedcentral.com
… Abstract. Background. stroke is among the leading causes of death and disability … Here, we aimed to investigate whether the use of laser Doppler flowmetry (LDF) and the occlusion time (60 vs. 45 min) affected outcome variability and mortality in a rat stroke model …
Thereafter, a 30 mm silicone coated 4–0 nylon suture (403756, Doccol, Redlands, CA, USA) was inserted in the CCA and advanced up the ICA.
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Effects of ischemic post‐conditioning on neuronal VEGF regulation and microglial polarization in a rat model of focal cerebral ischemia

E Esposito, K Hayakawa, BJ Ahn… - Journal of …, 2018 - Wiley Online Library
… for Flk1 inhibitor injection) exposed to postconditioning, and the other group of 41 rats exposed to standard post-stroke care … Ischemia was induced by introducing a 5-O surgical monofilament nylon suture (Doccol Corporation, Cat# 503856PK10) from the external carotid artery …
Cited by 1 Related articles All 3 versions

Patchouli alcohol protects against ischemia/reperfusion-induced brain injury via inhibiting neuroinflammation in normal and obese mice

L Wei, Y Chen, QY Yu, Y Wang, G Liu - Brain research, 2018 - Elsevier
… with systemic inflammation, which are associated with an unfavorable functional outcome and increased mortality after ischemic stroke (Dziedzic, 2015) … Briefly, silicone-coated monofilament (Doccol Corp, Redlands, CA) was inserted into the lumen via the right internal carotid …
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Targeted Temperature Management: Peltier's Element-Based Focal Brain Cooling Protects Penumbra Neurons from Progressive Damage in Experimental Cerebral …

M Tauchi, MM Tejada de Rink, H Fujioka… - Therapeutic …, 2018 - liebertpub.com
… Systemic cooling demonstrated efficacy in an experimental ischemic stroke (Clark et al., 2008, 2009), but it is challenging to achieve a desired … A silicone-coated 30 mm 4–0 nylon monofilament (Doccol Corp., Sharon, MA) was inserted into the right internal carotid artery through …
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Mito-Tempo prevents nicotine-induced exacerbation of ischemic brain damage

C Li, H Sun, G Xu, KD McCarter, J Li… - Journal of Applied …, 2018 - physiology.org
… INTRODUCTION 55 Tobacco smoking is a major risk factor for ischemic stroke (11, 49). Further, nicotine is 56 … The middle cerebral artery (MCA) was 119 occluded by inserting a monofilament suture (Doccol, MA, USA) into the internal carotid artery 120 …
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Cofilin-actin rod formation in neuronal processes after brain ischemia

SJ Won, AM Minnella, L Wu, CH Eun, E Rome… - bioRxiv, 2018 - biorxiv.org
… Our findings demonstrate robust and extensive 104 formation of cofilin-actin rods in neuronal processes in each of these stroke models, and … The distal part of 137 external carotid artery was ligated, and a silicon-coated 6-0 monofilament (Doccol Corporation …

[HTML] Influence of Low-Dose Alcohol Consumption on Post-Ischemic Inflammation: Role of Cystathionine γ-Lyase

KD McCarter, C Li, J Li, G Xu, H Sun - Alcohol, 2018 - Elsevier
… This dual effect generates a J-shaped pattern in the relationship between chronic alcohol intake and stroke incidence and prognosis … The MCA was occluded by inserting a silicon rubber-coated monofilament (Doccol Corporation, MA, USA) from the basal part of the external …

Beneficial Effects of Delayed P7C3-A20 Treatment After Transient MCAO in Rats

ZB Loris, JR Hynton, AA Pieper, WD Dietrich - Translational stroke …, 2018 - Springer
… previous findings and demonstrate for the first time a persistent therapeutic effect with delayed administration of P7C3-A20 after stroke in mitigating … incision was made in the ECA, and a 20-mm nylon monofilament with a silicone rubber-coated tip (Doccol Corporation, Sharon …
Cited by 2 Related articles All 4 versions

Genetic deletion of Krüppel-like factor 11 aggravates ischemic brain injury

X Tang, K Liu, MH Hamblin, Y Xu, KJ Yin - Molecular neurobiology, 2018 - Springer
… All stroke outcome assessments were performed in a blinded manner … A 2-cm length of a 6-0 rounded tip nylon suture (Doccol Corporation, Sharon, MA) was gently advanced from the internal carotid artery up to the origin of the middle cerebral artery (MCA) until regional CBF …
Cited by 3 Related articles All 3 versions

[PDF] Assessment of the MRI and Behavioral Test Results in a Focal Cerebral Ischemia-Reperfusion Model in the Rat after Separate and Combined Use of Mouse …

A Tahta, N Izgi, T Bagci-Onder, E Erdag… - Turkish …, 2018 - neurosurgery.dergisi.org
… Early administration of 3-hydroxy-3-methylglutaryl coenzyme- A reductase inhibitors (statins) reduces the infarct volume in experimental acute stroke models (8,10 … A 3.0 cm length of 4-0 monofilament nylon suture with a silicon-coated tip (Doccol Corp., Redlands, CA, USA) was …
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The non‐peptidic δ‐opioid receptor agonist Tan‐67 mediates neuroprotection post‐ischemically and is associated with altered amyloid precursor protein expression …

JW Min, Y Liu, D Wang, F Qiao… - Journal of …, 2018 - Wiley Online Library
… Transient middle cerebra artery occlusion (MCAO) ischemic stroke model … A 20 mm-long 7-0 silicon-coated monofilament suture (7020910PK5Re; Doccol Corporation, Sharon, MA, USA) was introduced into the left internal carotid artery through the common carotid artery to …
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[HTML] Generation and characterization of tissue-type plasminogen activator transgenic rats

Y Ito, K Noguchi, Y Morishima, K Yamaguchi - Journal of thrombosis and …, 2018 - Springer
… A nylon suture (4–0 fine MCAO suture L56PK10, Doccol Corporation) was inserted into the internal carotid artery (ICA) from the external carotid artery (ECA) to block blood flow into the MCA [25] … Dose-response of rt-PA in a thromboembolic stroke model …
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Faim2 contributes to neuroprotection by erythropoietin in transient brain ischemia

D Komnig, K Gertz, P Habib, KW Nolte… - Journal of …, 2018 - Wiley Online Library
… maintained in 1% isoflurane in 69% N 2 O and 30% O 2 . The ischemic insult was induced by an 8.0 nylon monofilament (Doccol Cat# 801912PK5 … 1a). In the stroke model, EPO was administered 30 min before, 24 and 48 h after MCAo (cumulative EPO doses 15 000 U/kg or …
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The membrane mesenchymal stem cell derived conditioned medium exerts neuroprotection against focal cerebral ischemia by targeting apoptosis

M Faezi, SN Maleki, N Aboutaleb… - Journal of chemical …, 2018 - Elsevier
… Although stem cell based therapies have shown safety and efficacy in stroke patients and experimental models, their clinical application might be challenged by concerns regarding … Silicon rubber-coated monofilament was obtained from Doccol company (Philadelphia, PA, USA …
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Deleterious role of endothelial lectin-like oxidized low-density lipoprotein receptor-1 in ischaemia/reperfusion cerebral injury

A Akhmedov, NR Bonetti, MF Reiner… - Journal of Cerebral …, 2018 - journals.sagepub.com
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is implicated in cardiovascular disease by modulating apoptosis and oxidative stress. We hypothe..
(Doccol MCAO suture was used for inducing the stroke model)
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[HTML] In vitro studies on space-conforming self-assembling silk hydrogels as a mesenchymal stem cell-support matrix suitable for minimally invasive brain …

I Osama, N Gorenkova, CM McKittrick… - Scientific reports, 2018 - nature.com
… One excellent model system is experimental stroke which provides a cavity for space conformity to be visualised … (a) Experimental timeline for the stroke model in rats, injection of 4% w/v self-assembling silk hydrogel and assessment …
Briefly, male Sprague-Dawley rats (n = 4, weight 240–290G, 8–9 weeks, Harlan, UK) underwent a right transient middle cerebral artery occlusion for 60 minutes by insertion of a propylene filament (Doccol Corporation; tip diameter with coating 0.33 +/− 0.02 mm), via the common carotid artery to the ostium of the middle cerebral artery in the circle of Willis.
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Zbtb20 Regulates Developmental Neurogenesis in the Olfactory Bulb and Gliogenesis After Adult Brain Injury

TR Doeppner, J Herz, M Bähr, AB Tonchev… - Molecular …, 2018 - Springer
… Notably, decreased levels of Zbtb20 in transgenic mice lead to a reduced post- stroke gliogenic scar, suggesting a requirement of Zbtb20 for … of the middle cerebral artery was achieved using a 7–0 silicon coated nylon monofilament (180-μm tip diameter; Doccol, USA), which...

[HTML] Cerebral blood perfusion deficits using dynamic susceptibility contrast MRI with gadolinium chelates in rats with post-ischemic reperfusion without significant …

S Jin, MS Kang, HJ Cho - PloS one, 2018 - journals.plos.org
… MRI acquisition was performed before the two DSC-MRI acquisitions in the additional stroke group (n = 3). Rats in the stroke group were subjected to 1-h intraluminal monofilament (0.35 mm diameter filament, Doccol Corporation, USA) MCAO followed by 1-day reperfusion …
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Oral administration of a novel lipophilic PPARδ agonist is not neuroprotective after rodent cerebral ischemia

S Knauss, M Endres, F Blaschke… - Journal of Cerebral …, 2018 - journals.sagepub.com
Peroxisome proliferator-activated receptors are regulators of inflammatory signaling. This has fostered hope that PPAR agonists might have neuroprotective poten..
(Doccol MCAO suture was used for inducing the stroke model)
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Mechanism of Tau Hyperphosphorylation Involving Lysosomal Enzyme Asparagine Endopeptidase in a Mouse Model of Brain Ischemia

G Basurto-Islas, J Gu, YC Tung, F Liu… - Journal of Alzheimer's …, 2018 - content.iospress.com
… AEP also truncates tau by cleaving at Asn-255 and 368 [26] and mediates stroke-provoked I 2 PP2A cleavage and cell death in the … A 6-0 nylon suture with silicon coating (Doccol Corporation, Redlands, CA) was inserted into the internal carotid artery through the external carotid …
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[HTML] TOPK Promotes Microglia/Macrophage Polarization towards M2 Phenotype via Inhibition of HDAC1 and HDAC2 Activity after Transient Cerebral Ischemia

Z Han, H Zhao, Z Tao, R Wang, Z Fan, Y Luo… - Aging and …, 2018 - ncbi.nlm.nih.gov
… The present study was designed to test this hypothesis and explored possible therapeutic targets for the treatment of ischemic stroke … In brief, a silicon rubber-coated monofilament (diameter: 0.21 ± 0.02 mm; Doccol, CA) was inserted into the right external carotid artery lumen …
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Z‐Guggulsterone attenuates astrocytes‐mediated neuroinflammation after ischemia by inhibiting toll‐like receptor 4 pathway

T Liu, M Liu, T Zhang, W Liu, H Xu, F Mu… - Journal of …, 2018 - Wiley Online Library
… However, the mechanisms that regulate TLR4 expression still uncertainty in ischemic stroke. According to previous evidences, LPS enhanced TLR4 expression in human aortic smooth … cerebral artery (MCA) was occluded by inserting a 4-0 monofilament nylon suture (Doccol …
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Endothelial nitric oxide synthase inhibition triggers inflammatory responses in the brain of male rats exposed to ischemia‐reperfusion injury

R Greco, C Demartini, AM Zanaboni… - Journal of …, 2018 - Wiley Online Library
… Pharmacological inhibition or gene deletion of miR-155 promotes functional recovery in ischemic stroke models by improving microvascular … A silicone-coated nylon filament (diameter: 0.37 mm; Doccol Corporation, Redlands, CA) was introduced through the external carotid …
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Contractile Responses in Spontaneously Hypertensive Rats after Transient Middle Cerebral Artery Occlusion

AS Grell, M Mostajeran, L Edvinsson, S Ansar - Pharmacology, 2018 - karger.com
… In response to acute ischemic stroke or hypertension endothelin 1 and angiotensin II contribute to impaired vasculature through, for … A silicon rubber-coated monofilament (Doccol Corporation, Redlands, CA, USA) was inserted in the external carotid artery and advanced into the …
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Monocarboxylate transporter 1 and the vulnerability of oligodendrocyte lineage cells to metabolic stresses

P Zhou, T Guan, Z Jiang, M Namaka… - CNS neuroscience&  …, 2018 - Wiley Online Library
… with isoflurane (1.5%-2%), and rectal temperature was maintained at 37°C. A 6-0 silicone-coated nylon monofilament (Doccol, Sharon, MA … the human SOD1 gene,[10, 11] is associated with axon injury and neuronal loss.[2, 12] Ischemic conditions such as stroke create stresses …
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Let-7i inhibition enhances progesterone-induced functional recovery in a mouse model of ischemia

T Nguyen, C Su, M Singh - Proceedings of the National …, 2018 - National Acad Sciences
… progesterone | BDNF | Pgrmc1 | ischemic stroke | let-7i stroke has been reported as one of the leading causes of death and a major cause of disability in the United States (1), costing approximately $34 billion annually (according to the Centers for Disease Control) …
The left MCA was occluded by a 6-0 monofilament suture (Doccol. Corporation) introduced via the internal carotid artery.
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[PDF] Characterization of the rat cerebrospinal fluid proteome following acute cerebral ischemia using an aptamer-based proteomic technology

A Simats, T García-Berrocoso, L Ramiro, D Giralt… - Scientific reports, 2018 - nature.com
… we have been able to firstly identify and primary evaluate the role of three promising proteins as stroke blood biomarkers … The following day, a silicone-coated nylon filament (Doccol Corporation, reference number: 403723PK10) was intro- duced through the external carotid …
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Neuroprotective effects of protein tyrosine phosphatase 1B inhibitor on cerebral ischemia/reperfusion in mice

M Sun, H Izumi, Y Shinoda, K Fukunaga - Brain research, 2018 - Elsevier
… Furthermore, KY-226 attenuated the generation of reactive oxygen species (ROS) in mouse cortex. These results suggest that KY-226 may act as a novel therapeutic candidate for ischemic stroke … Keywords. KY-226. Akt. eNOS. ERK. stroke. ROS. 1. Introduction …
Then the tMCAO surgical procedure was performed as follows: a 6–0 suture (Doccol Corporation, USA) coated with silicone was inserted from the right external carotid artery to the internal carotid artery, extending to the origin of middle cerebral artery, for 2 h. After 2 h, the suture was removed, allowing reperfusion to occur.
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Sustained (S)-roscovitine delivery promotes neuroprotection associated with functional recovery and decrease in brain edema in a randomized blind focal cerebral …

E Rousselet, A Létondor, B Menn… - Journal of Cerebral …, 2018 - journals.sagepub.com
Stroke is a devastating disorder that significantly contributes to death, disability and healthcare costs. In ischemic stroke, the only current acute therapy is...
(Doccol MCAO suture was used for inducing the stroke model)
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High-speed widefield photoacoustic microscopy of small-animal hemodynamics

B Lan, W Liu, Y Wang, J Shi, Y Li, S Xu… - Biomedical Optics …, 2018 - osapublishing.org
… Using this hexagon-scanner-based OR-PAM system, we have imaged epinephrine-induced vasoconstriction in the whole mouse ear and vascular reperfusion after ischemic stroke in the mouse cortex in vivo, with a high spatial resolution and high volumetric imaging speed …
Then, a silicon-coated nylon monofilament (Doccol, Sharon, MA, USA) was introduced through a small incision into the common carotid artery and advanced to the bifurcation of anterior cerebral artery and MCA to block blood flow to the MCA territory in the left hemisphere of the mouse brain. 
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Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration

F Herisson, V Frodermann, G Courties, D Rohde… - Nature …, 2018 - nature.com
… While bone marrow production and release of leukocyte increases after stroke, it is currently unknown whether its activity rises homogeneously throughout the entire hematopoietic system … 6). Fig. 3: Skull releases more inflammatory cells after stroke. Fig. 3 …
(Doccol MCAO suture was used for inducing the stroke model)
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Detrimental effects of 2-arachidonoylglycerol on whole blood platelet aggregation and on cerebral blood flow after a focal ischemic insult in rats

JA Shearer, SJ Coker, HVO Carswell - American Journal of …, 2018 - physiology.org
… Animals Male adult Sprague-Dawley rats (stroke study: n 30 and platelet aggregation study: n 40) were obtained from in-house breeding in the … Permanent MCAO was induced by a 5-0 silicon-coated monofilament (50-3033, Doccol, Sharon, MA), which was inserted into the left …
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Sensorimotor functional and structural networks after intracerebral stem cell grafts in the ischemic mouse brain

C Green, A Minassian, S Vogel… - Journal of …, 2018 - Soc Neuroscience
… 137 138 Transient middle cerebral artery occlusion 139 After MRI baseline measurements, focal ischemic stroke was initiated by transient occlusion of the 140 … A 143 rubber-coated filament (length of 20 mm, diameter of 170 μm at the tip, Doccol Corp., Sharon, USA) 144 …
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Repression of adenosine triphosphate–binding cassette transporter ABCG2 by estrogen increases intracellular glutathione in brain endothelial cells following …

JA Shin, S Im Jeong, HW Kim, G Jang, DR Ryu… - Neurobiology of …, 2018 - Elsevier
… In addition, we examined glutathione levels in brain microvessels after ischemic stroke in young and aged female mice … A 6-0 silicon-coated black monofilament surgical suture (Doccol Corporation, Redlands, CA, USA) was inserted into the exposed right external carotid artery …
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Long-term treatment of diabetic rats with vanadyl sulfate or insulin attenuate acute focal cerebral ischemia/reperfusion injury via their antiglycemic effect

H Ahmadi-Eslamloo, GA Dehghani… - Metabolic brain disease, 2018 - Springer
… The scores of neurological deficits after acute ischemic stroke were also higher in patient with insulin resistance compared to … neck incision and exposing the right common external carotid artery, a silicon coated nylon thread (4043PK5Re, Doccol Corporation, Pennsylvania …
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Metabolomic Analysis of Mouse Brain after a Transient Middle Cerebral Artery Occlusion by Mass Spectrometry Imaging

T ABE, K NIIZUMA, A KANOKE, D SAIGUSA… - Neurologia medico …, 2018 - jstage.jst.go.jp
… Classically, various signaling pathways after stroke are analyzed mainly at the message level using polymerase chain reaction or at the protein … a vascular clip (MH-1-20, BEAR Medic, Tokyo), and a silicon-coated 6-0 nylon monofilament (602345PK5Re, Doccol, Redlands, CA …
Cited by 1 All 4 versions

Inhibition of miR-141-3p Ameliorates the Negative Effects of Poststroke Social Isolation in Aged Mice

R Verma, RM Ritzel, NM Harris, J Lee, TH Kim, G Pandi… - stroke, 2018 - Am Heart Assoc
… Advanced Search. Donate. stroke logo. Hello Guest! MY ALERTS. SIGN IN; JOIN … Submission Site; Author Reprints; Webinar Series. HomestrokeVol. 49, No. 7Inhibition of miR-141-3p Ameliorates the Negative Effects of Poststroke Social Isolation in Aged Mice. No Accessarticle …
(Doccol MCAO suture was used for inducing the stroke model)

Protective effects of ex‐527 on cerebral ischemia–reperfusion injury through necroptosis signaling pathway attenuation

S Nikseresht, F Khodagholi… - Journal of cellular …, 2018 - Wiley Online Library
… Our findings also imply the potential therapeutic use of ex‐527 to abolish the mortality rate in brain stroke … a neck midline incision, the right common carotid artery and its bifurcations were exposed, and then an intraluminal silicone‐coated suture (403934PK; Doccol, Sharon, MA …
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Brain investigations of rodent disease models by chemical exchange saturation transfer at 21.1 T

T Roussel, JT Rosenberg, SC Grant… - NMR in …, 2018 - Wiley Online Library
… By contrast, the changes in MTRasym did not reach statistical sig- nificance in the stroke cases, providing much weaker reporters than T2 or diffusion … A 3.0‐cm filament with a 0.35‐mm‐thick and 2–3 mm‐long rubber coating (Doccol Corp., Redlands, CA) was inserted through …
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Iron released from reactive microglia by noggin improves myelin repair in the ischemic brain

JA Shin, YA Kim, HW Kim, HS Kim, KE Lee, JL Kang… - …, 2018 - Elsevier
… the BMP/hepdicin pathway in reactive microglia/macrophages and remyelination in the brain during the recovery phase after ischemic stroke … Briefly, a 6-0 silicon-coated black monofilament surgical suture (Doccol Cooperation, Redlands, CA, USA) was wedged into the circle of …
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[HTML] A diseasome cluster-based drug repurposing of soluble guanylate cyclase activators from smooth muscle relaxation to direct neuroprotection

F Langhauser, AI Casas, E Guney, J Menche… - NPJ systems biology …, 2018 - nature.com
… Results. Human diseasome and protein interactome of sGC in stroke … sGC activity and protein levels in ischemic stroke. We examined whether upon ischemic stroke, any abnormalities in sGC become apparent that could suggest sGC as a mechanism-based target …
Following a midline skin incision in the neck, the proximal common carotid artery and the external carotid artery were ligated and a standardized silicon rubber-coated 6.0 nylon monofilament (6021; Doccol) was inserted and advanced via the right internal carotid artery to occlude the origin of the right MCA. t
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[HTML] Vesicular glutamate release from central axons contributes to myelin damage

S Doyle, DB Hansen, J Vella, P Bond, G Harper… - Nature …, 2018 - nature.com
… source of glutamate in this context is unknown. Myelin damage results in permanent action potential loss and severe functional deficit in the white matter of the CNS, for example in ischemic stroke. Here, we show that in rats and …
The proximal portions of the left common carotid and the external carotid arteries were ligated and a 6–0 silicon-coated nylon suture (60SPRePK5-21910, Doccol Corporation, Massachusetts, USA) introduced into the internal carotid artery to occlude the middle cerebral artery at its origin.
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[HTML] SUR1-TRPM4 channel activation and phasic secretion of MMP-9 induced by tPA in brain endothelial cells

V Gerzanich, MS Kwon, SK Woo, A Ivanov, JM Simard - PloS one, 2018 - journals.plos.org
… In humans with stroke and in rodent models of stroke, the SUR1 inhibitor, glibenclamide, has been found to reduce hemorrhagic … MCAo was obtained using a commercially available intra-arterial occluder (0.39 mm; 4039PK5Re; Doccol Corp, Redlands CA) inserted retrograde …
Cited by 2 Related articles All 8 versions

A-Kinase-Anchoring Protein (AKAP150) is expressed in astrocytes and upregulated in response to ischemia

AF Rivera-Pagán, MP Méndez-González… - Neuroscience, 2018 - Elsevier
… Transient Middle Cerebral Artery Occlusion (tMCAO) to simulate stroke in vivo: Adult Sprague-Dawley male rats (250-300 g) were anesthetized with 5 … A piece of monofilament suture (Doccol) was inserted into the lumen of the stump and advanced into the internal carotid artery …
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[HTML] Genome-wide transcriptome analysis using RNA-Seq reveals a large number of differentially expressed genes in a transient MCAO rat model

LV Dergunova, IB Filippenkov… - BMC …, 2018 - bmcgenomics.biomedcentral.com
… Numerous studies have demonstrated the role of individual genes and associated signaling pathways in the pathogenesis of ischemic stroke … The tMCAO model reflects events that occur in ischemic stroke in humans in the treatment of thrombolytic agents [14, 15] …
The transient cerebral ischemia rat model was induced by endovascular occlusion of the right middle cerebral artery using a monofilament (Doccol Corporation, USA) for 90 min, and subsequent reperfusion for 3 or 22.5 h using the method of Koizumi et al., [45] with modifications.
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Treatment duration affects cytoprotective efficacy of positive allosteric modulation of α7 nAChRs after focal ischemia in rats

N Gaidhani, VV Uteshev - Pharmacological research, 2018 - Elsevier
… To minimize irreversible brain injury after acute ischemic stroke (AIS), the time to treatment (ie, treatment delay) should be minimized … AIS Acute ischemic stroke. MCAO middle cerebral artery occlusion. PAM positive allosteric modulator. TTC 235-triphenyltetrazolium chloride …
(Doccol MCAO suture was used for inducing the stroke model)
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Pentose phosphate pathway activation via HSP27 phosphorylation by ATM kinase: A putative endogenous antioxidant defense mechanism during cerebral ischemia …

Y Yamamoto, K Hosoda, T Imahori, J Tanaka, K Matsuo… - Brain Research, 2018 - Elsevier
… An ATM inhibitor increased infarct size after ischemia-reperfusion. Abstract. Molecular mechanism underlying ischemic stroke remains poorly understood … These findings have important implications for treatment of stroke. Previous article in issue; Next article in issue …
(Doccol MCAO suture was used for inducing the stroke model)
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[HTML] Contributions of the hippocampal CA3 circuitry to acute seizures and hyperexcitability responses in mouse models of brain ischemia

H Song, SM Mylvaganam, J Wang… - Frontiers in cellular …, 2018 - ncbi.nlm.nih.gov
… Mice have been increasingly used in stroke research largely because genetic and molecular manipulations in mouse models offer great advantages in … To induce pMCAO, a silicon-coated fine suture (#6, Doccol Corporation, Redlands, CA, USA) was inserted into the common …
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Preliminary in vivo magnetofection data using magnetic calcium phosphate nanoparticles immobilizing DNA and iron oxide nanocrystals

QTH Shubhra, A Oyane, M Nakamura, S Puentes… - Data in brief, 2018 - Elsevier
… A ribbon knot was placed in the distal CCA and an arteriotomy was performed in the proximal CCA, followed by the insertion of a silicone-coated monofilament (6023-PK5, Doccol Corporation, USA) which was fixed by a silk knot … Jpn. J. stroke, 8 (1986), pp …
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Propofol Prevents Oxidative Stress by Decreasing the Ischemic Accumulation of Succinate in Focal Cerebral Ischemia–Reperfusion Injury

W Yu, D Gao, W Jin, S Liu, S Qi - Neurochemical research, 2018 - Springer
… Ischemia–reperfusion (IR) injury is the primary health issue that occurs after events such as stroke, cardiac arrest and resuscitation, and organ … MCAO was induced with a silicone-coated monofilament (40-3734 PK 10, Doccol Corporation, Pennsylvania Ave., Redlands, CA, USA …
Cited by 2 Related articles All 3 versions

[PDF] King's Research Portal

T Jin, FJ Nicholls, WR Crum, H Ghuman, SF Badylak… - core.ac.uk
… cerebral artery (MCA) occlusion, a rat model of stroke [26]. For this, under isoflurane (4% induction, 1% maintenance in 30% O2) anesthesia, a 5-0 silicon rubber-coated monofilament (503556PK10, Doccol, USA) was advanced to the …
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Impact of the receptor tyrosine kinase EphB2 on cerebral ischemia in mice

AS Ernst - 2018 - archiv.ub.uni-heidelberg.de
… 45 4 Results ..... 46 4.1 Analysis of progression of stroke in Ephb2-deficient mice … 59 4.4 EphB2 activation in the early hyperacute phase after stroke …
Then, a 7-0 silicon rubber-coated monofilament (Doccol Corporation) was induced into the left CCA and pushed through the ICA towards the middle cerebral artery.t

Regional Differences in Na+/K+-ATPase Expression in the Mouse and Rat Brain

M Golod - 2018 - qspace.library.queensu.ca
… not all brain regions are similarly vulnerable to ischemic injury. During stroke, failure of the Na+/K+-ATPase generates a robust anoxic depolarization that silences neurons in higher … This may help identify molecular targets for improving higher brain survival post stroke. Page 4 …
A silicon rubber-coated monofilament (L23, Doccol Corporation, Massachusetts, USA, size 4-0, diameter 0.185mm,  length 30mm, diameter with coating 0.41+/-0.02mm, coating  length 2-3mm) was maneuvered into the MCA(~20mm  insertion to occlude blood flow for 90 minutes.

[PDF] 新 規人工酸素運搬体 HemoAct を用いた脳虚血再灌流障害治療開発に関する研究

月花正幸 - 2018 - eprints.lib.hokudai.ac.jp
… Albumin-cluster 学会名;International stroke Conference 2017, 22th, Feb, 2017, Houston, Geoge R. Brown Convention Center … した(4-0 ナイロン糸が先 端径 0.37 ㎜にシリコンコーティングされているもの: Doccol Corp., Redlands, CA, USA)。tMCAO の手術手技において、糸栓子の先 …
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Studies on thrombopoiesis and spleen tyrosine kinase-mediated signaling in platelets

JMM van Eeuwijk - 2018 - opus.bibliothek.uni-wuerzburg.de
… Platelets play an essential role in hemostasis and thrombosis, but also in the pathogenesis of ischemic stroke. Ischemic stroke, which is mainly caused by thromboembolic occlusion of … arterial thrombosis and a critical determinant of stroke outcome, making its signaling pathway …The duration of the surgical procedure per animal was kept below 15 min. A silicon rubber–coated 6.0 nylon monofilament (6021PK10, Doccol, Redlands,  CA,  USA) was advanced through the right common carotid artery and the internal carotid artery up to the origin of the middle cerebral artery (MCA) causing an MCA  occlusion. After an occlusion time of 6 0 min, the filament was removed all owing reperfusion.

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